The Agency has been set-up by the European Commission to manage on its behalf several EU programmes.

• Most of COSME, the EU programme for the Competitiveness of Enterprises and Small and Medium-sized Enterprises (SMEs), including Enterprise Europe Network (EEN), Your Europe Business;
• Part of Horizon 2020, the EU Framework Programme for Research and Innovation, and in particular:
  • Part II 'Industrial leadership':
    • Innovation in SMEs (including the European IPR Helpdesk and Peer learning for innovation agencies)
    • The Sustainable Industry Low Carbon Scheme (SILC II)
    • part of the Leadership in Enabling and Industrial Technologies
  • Part III 'Societal challenges':
    • The Energy Efficiency part of the challenge ‘Secure, Clean and Efficient Energy’;
    • The calls for proposals in the fields of waste, water innovation and sustainable supply of raw materials under the challenge ‘Climate action, Environment, Resource Efficiency and Raw Materials’
  • The SME instrument
• Part of the EU programme for the Environment and Climate action (LIFE)
• Part of the European Maritime and Fisheries Fund (EMFF)
• The legacy of the Intelligent Energy – Europe programme and the Eco-innovation initiative

The EASME also organises the EU Sustainable Energy Week (EUSEW)